Table 4.
Details of the predictive model used to calculate the probability of IAC in pGGNs measurements ≤ 2 cm
| Risk factors | Estimate | Std. Error | Statistic | OR (95% CI) | p |
|---|---|---|---|---|---|
| Intercept | -12.759 | 4.13 | 0 | 0.002 | |
| Maximum diameter | 2.41 | 0.417 | 5.784 | 11.130 (5.044, 25.966) | < 0.001 |
| Age | 0.053 | 0.018 | 2.871 | 1.054 (1.018, 1.094) | 0.004 |
| Lymphocyte | -0.027 | 0.308 | -0.089 | 0.973 (0.527, 1.769) | 0.929 |
| PNI | 0.081 | 0.042 | 1.931 | 1.084 (1.002, 1.183) | 0.054 |
| Erythrocyte | 0.787 | 0.543 | 1.449 | 2.196 (0.759, 6.471) | 0.147 |
| Hemoglobin | -0.025 | 0.018 | -1.414 | 0.975 (0.941, 1.010) | 0.157 |
| SA | 0.049 | 0.024 | 2.049 | 1.050 (1.002, 1.100) | 0.04 |
| CYFRA21-1 | 0.209 | 0.158 | 1.321 | 1.232 (0.911, 1.705) | 0.186 |
| CEA | 0.094 | 0.112 | 0.84 | 1.099 (0.877, 1.366) | 0.401 |
| Gender | |||||
| Female | Ref. | ||||
| Male | 0.768 | 0.47 | 1.633 | 2.154 (0.859, 5.458) | 0.103 |
| Smoking history | |||||
| Non-smoker | Ref. | ||||
| Smoker | -0.327 | 0.435 | -0.751 | 0.721 (0.304, 1.685) | 0.453 |
| Blood type | |||||
| A | Ref. | ||||
| B | 0.582 | 0.368 | 1.582 | 1.790 (0.875, 3.722) | 0.114 |
| AB | 0.857 | 0.49 | 1.749 | 2.356 (0.898, 6.187) | 0.08 |
| O | -0.278 | 0.386 | -0.72 | 0.757 (0.352, 1.609) | 0.472 |
| ASA | |||||
| 1 | Ref. | ||||
| 2 | -0.855 | 0.526 | -1.625 | 0.425 (0.153, 1.222) | 0.104 |
| 3 | 0.345 | 1.586 | 0.218 | 1.412 (0.045, 46.131) | 0.828 |
| Location | |||||
| Centrality | Ref. | ||||
| Peripherality | -1.245 | 0.515 | -2.418 | 0.288 (0.104, 0.794) | 0.016 |
| Shape | |||||
| Regularity | Ref. | ||||
| Irregularity | 0.444 | 0.327 | 1.358 | 1.559 (0.819, 2.962) | 0.174 |
| Spiculation | |||||
| No | Ref. | ||||
| Yes | 0.253 | 0.309 | 0.819 | 1.288 (0.699, 2.360) | 0.413 |
| Vascular penetration sign | |||||
| No | Ref. | ||||
| Yes | -0.601 | 0.346 | -1.736 | 0.549 (0.275, 1.074) | 0.083 |
| Pleural adhesions | |||||
| No | Ref. | ||||
| Yes | 0.935 | 0.308 | 3.034 | 2.548 (1.398, 4.700) | 0.002 |
| Bronchus sign | |||||
| No | Ref. | ||||
| Yes | 0.979 | 0.373 | 2.625 | 2.662 (1.286, 5.576) | 0.009 |
| Lobulation | |||||
| No | Ref. | ||||
| Yes | 0.815 | 0.38 | 2.147 | 2.260 (1.078, 4.799) | 0.032 |
IAC Invasive adenocarcinoma, COPD Chronic obstructive pulmonary diseases, ASA American Society of Anesthesiologists, PNI Prognostic nutritional index, NLR Neutrophil-lymphocyte ratio, PLR Platelet-lymphocyte ratio, MLR Monocyte-lymphocyte ratio, dNLR derived neutrophil-to-lymphocyte ratio, NLPR Neutrophil to lymphocyte and platelet ratio, SIRI Systemic inflammatory response syndrome, AISI Aggregate index of systemic inflammation, SII Systemic inflammation index, PIV Pan-immune-inflammation value, LDH Lactate dehydrogenase, SA Serum amyloid, 5'-NT 5'-nucleotidase, Pro-GRP Pro-gastrin-releasing peptide, SCC Squamous cell carcinoma, Cyfra21-1 Cytokeratin 19-fragments, CEA Carcinoembryonic antigen, CA125 Carcinoma antigen 125, NSE Neuron-specific enolase, BMI Body mass index, FEV1 Forced expiratory volume in one second, MVV Maximal voluntary ventilation