Fig. 2.

The associations between HLI, inflammation markers and breast cancer. The panel presents the relationship between HLI and breast cancer, and mediation through CRP, CAR, CLR, SII, MHR, NHR. Mediation effects are decomposed into controlled direct effects, pure interaction, mediated interaction, and pure indirect effects. The panel (A), (B), (C), (D), (E) and (F) present the results of mediation analyses between HLI, inflammation markers and breast cancer. Standardized coefficients, proportion of mediation and interaction are presented in the figure. ***indicates a P value < 0.001, ** indicates a P value < 0.01, * indicates a P value < 0.05. The detailed results are provided in Supplementary Table 10