Table 1.
Patient Cohort Demographics
| Control | Mild-Moderate COPD | Emphysema without Airway Obstruction | P Value | |
|---|---|---|---|---|
| N | 6 | 5 | 5 | — |
| Age, yr | 68 ± 9 | 71 ± 11 | 64 ± 8 | 0.68 |
| Sex, % F | 83 | 100 | 60 | 0.27 |
| GOLD category | ||||
| I | — | 2 | — | — |
| II | — | 3 | — | — |
| BMI, kg/m2 | 27 ± 4.4 | 27 ± 2.4 | 28 ± 3.9 | 0.66 |
| Spirometry | ||||
| FEV1% predicted | 92 ± 18 | 78 ± 16 | 73 ± 23 | 0.36 |
| FEV1/FVC, % | 72 ± 4 | 60 ± 6 | 70 ± 8 | 0.0014 |
| Home oxygen | None | None | None | — |
| Smoking status | ||||
| Ever-smoker | 2 | 5 | 5 | 0.012 |
| Current smoker | 1 | 3 | 2 | 0.33 |
| Pack-years | 9.3 ± 22 | 33 ± 12 | 45 ± 13 | 0.038 |
| Inhaled medications | ||||
| Corticosteroid | 1 | 1 | 1 | 0.99 |
| Bronchodilator | 2 | 2 | 2 | 0.97 |
| Oral corticosteroids | 0 | 0 | 1 | 0.31 |
| Diagnosis of lung mass | ||||
| Malignant | 5 | 5 | 4 | 0.59 |
| Benign | 1 | 0 | 1 | — |
Definition of abbreviations: BMI = body mass index; COPD = chronic obstructive pulmonary disease; GOLD = Global Initiative for Chronic Obstructive Lung Disease.
Data are shown as mean ± SD or n. Kruskal-Wallis testing for continuous variables (age, BMI, spirometry). Chi-square tests for categorical variables (sex, smoking status, medications, diagnosis of lung mass). Comparisons with P value < 0.05 are in boldface.