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. 2024 Feb 14;16(1):2313769. doi: 10.1080/19490976.2024.2313769

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 5. — MyD88 deficiency eliminates the effects of metronidazole treatment on melatonin production.

(a) Diagram for the description of metronidazole treatment in Myd88^flox/flox and Myd88^ΔIEC mice. (b and c) The level of melatonin in the serum (b) and colon (c) of Myd88^flox/flox and Myd88^ΔIEC mice treated with metronidazole or not (n = 4-10). (d) The protein abundance of MyD88, AANAT, p-p65 and p65 in the colon of Myd88^flox/flox and Myd88^ΔIEC mice treated with metronidazole or not (n = 3). (e) Confocal microscopy analysis of MyD88 (purple), AANAT (green), and Villin (red) in the colon tissue of Myd88^flox/flox and Myd88^ΔIEC mice treated with metronidazole or not. Scale bars, 5 μm (n = 10-12). Data were analyzed by Kruskal-Wallis (b) or one-way ANOVA (c-e) and represented as mean ± SD. *p < .05, **p < .01, ***p < .001.