Figure 6.

Contact domain of TRPV4. a, the cytoplasmic domains and helices S1 and S6 of the mouse and human TRPV4 channel are represented. b, zoomed-in views of the coupling domain (CD), where the β1 and β2 strands of the N-terminal regions interact with the β3 strand of the C-terminal region, which brings these two regions closer to each other. The arrangement of the tertiary structure allows certain domains such as the TRP box to come into contact with key areas of the protein for its regulation. The black arrows represent the movement of the TRP box toward the plasma membrane facilitated by the HLH motif. PDB: 8J1D and 8T1B (resolutions of 3.59 Å and 3.00 Å, respectively) [52,127]. Created with PyMOL and BioRender.com.