Figure 10.

The “vanilloid pocket” in TRPV4. a, schematic representation of the apo structure of human TRPV4 channel in a parallel view with the membrane. Each subunit of the homotetramer is shown by a different color. A zoom-in of the ligand binding pocket between the S1–S4 and the TRP box where key amino acid residues for the binding of b, endogenous (pink ribbons, orange sticks) or c, synthetic (cyan ribbons, orange sticks) ligands are represented. The chemical structures of the modulators of the TRPV4 channel discussed in this review are shown as well. PDB: 8T1B (resolution 3.00 Å) [52]. Created with PyMOL and BioRender.com.