Fig. 3.

Cartilage regeneration upon salamander limb amputation: The process of cartilage regeneration in juvenile axolotls starts with the remodelling and histolysis of non-functional tissues. Signals from the WE induce an inflammatory response and promote skeletal resorption by osteoclasts. Simultaneously, migration of skeletal progenitors from the perichondrium and interstitial space results in the condensation of the new skeleton by differentiation into cartilage cells. Contribution of these progenitors is differential along the proximo-distal axis. The success of the integration of the newly formed cartilage is influenced by skeletal resorption. Created with BioRender.com.