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. Author manuscript; available in PMC: 2024 Feb 15.
Published in final edited form as: Nat Struct Mol Biol. 2023 May 1;30(6):778–784. doi: 10.1038/s41594-023-00989-7

Fig. 3. Catalytic-competent conformation of the AtAgo10-guide-target complex.

Fig. 3.

a. Schematic of major contacts between AtAgo10 and the guide (red) and target (blue) RNAs. Residues colored by domain, as in Fig. 1. b. Structure of the AtAgo10-guide-target central-duplex conformation. Insets detail protein-RNA contacts specific to the central-duplex conformation. c. Sequence alignment of select plant and animal AGO and PIWI proteins. AtAgo10 residues contacting t9-t14 are indicated. Residues forming L1 hairpin and cS7 are also indicated. Shaded residues are identical to AtAgo10.