Table 3.
List of variants/missense mutations in genes that are associated with antifungal drug resistance or virulence in drug-tolerant isolates of C. glabrata in Qatar
|
Strain |
Gene ID |
Mutations |
Annotation |
|---|---|---|---|
|
CGBA21 |
CAGL0K00110g |
c.1646A>T_p.Gln549Leu |
Adhesive proteins |
|
CGBA21 |
CAGL0M08756g |
c.488G>A_p.Ser163Asn |
Glycoside hydrolases II |
|
CGBA12 |
CDR1 |
c.1333G>A_p.Asp445Asn |
Multidrug transporter of ATP-binding cassette superfamily, involved in resistance to azoles |
|
CGBA12 |
CDR2 |
c.82C>T_p.Arg28Cys |
Multidrug transporter, involved in fluconazole resistance |
|
CGBA12 |
CAGL0I00220g |
c.322G>A_p.Asp108Asn |
Adhesive proteins |
|
CGBA12 |
CAGL0I10340g |
c.998C>A_p.Thr333Lys |
Adhesive proteins |
|
CGBA12 |
CAGL0I10340g |
c.1067G>A_p.Gly356Glu |
Adhesive proteins |
|
CGBA12 |
CAGL0I10340g |
c.1609G>A_p.Asp537Asn |
Adhesive proteins |
|
CGBA12 |
CAGL0G04125g |
c.434A>C_p.Gln145Pro |
Adhesive proteins |
|
CGBA12 |
CAGL0J02508g |
c.2236G>A_p.Gly746Ser |
Adhesive proteins |
|
CGBA12 |
CAGL0K13024g |
c.1121C>G_p.Thr374Arg |
Adhesive proteins |
|
CGBA12 |
CAGL0K13024g |
c.1747T>C_p.Tyr583His |
Adhesive proteins |
|
CGBA12 |
CAGL0K13024g |
c.2854G>A_p.Val952Ile |
Adhesive proteins |
|
CGBA12 |
CAGL0E01595g |
c.1267C>T_p.Pro423Ser |
Glycoside hydrolases II |
|
CGBA12 |
CAGL0E01595g |
c.1387G>A_p.Val463Ile |
Glycoside hydrolases II |
|
CGBA12 |
CAGL0C02211g |
c.1409C>G_p.Ala470Gly |
Glycoside hydrolases II |
|
CGBA12 |
CAGL0E01419g |
c.50C>T_p.Ala17Val |
Partial aspartic protease |
|
CGBA31 |
SNQ2 |
c.1466C>T_p.Ser489Phe |
Involved in Pdr1p-mediated azole resistance |
|
CGBA31 |
CAGL0I00220g |
c.397A>C_p.Asn133His |
Adhesive proteins |
|
CGBA31 |
CAGL0K13024g |
c.370A>G_p.Asn124Asp |
Adhesive proteins |
|
CGBA31 |
CAGL0K13024g |
c.1184C>T_p.Ser395Leu |
Adhesive proteins |
|
CGBA31 |
CAGL0K13024g |
c.1585G>A_p.Asp529Asn |
Adhesive proteins |
|
CGBA31 |
CAGL0K13024g |
c.1589A>T_p.Lys530Ile |
Adhesive proteins |
|
CGBA31 |
CAGL0M03773g |
c.428C>T_p.Thr143Ile |
Unknown |
|
CGBA20 |
PDR1 |
c.1744G>C_p.Val582Leu |
Zinc finger transcription factor; regulates drug efflux pumps and controls multi-drug resistance |
|
CGBA53 |
PDR1 |
c.1661A>G_p.Asp554Gly |
Zinc finger transcription factor; regulates drug efflux pumps and controls multi-drug resistance |
|
CGBA11 |
CAGL0K00110g |
c.547G>C_p.Val183Leu |
Adhesive proteins |
|
CGBA5 |
ERG6 |
c.514G>T_p.Asp172Tyr |
Mutation confers resistance to amphotericin B and cell-wall-affecting drugs |
|
CGBA5 |
CAGL0E01793g |
c.1267A>G_p.Ile423Val |
Aspartic proteases |
|
CGBA5 |
CAGL0A03608g |
c.515C>T_p.Pro172Leu |
Unknown |
|
CGBA40 |
CAGL0M04191g |
c.1663A>T_p.Asn555Tyr |
Aspartic proteases |