Table 5.
List of common mutations associated with antifungal drug resistance in the higher MIC group
|
Gene |
ID |
POS |
REF |
ALT |
No. of REF |
No. of ALT |
HGVS.c |
HGVS.p |
|---|---|---|---|---|---|---|---|---|
|
CDR2 |
CAGL0F02717g |
NC_006029::263 877 |
A |
T |
1 |
16 |
c.2517A>T |
p.Glu839Asp |
|
PDR1 |
CAGL0A00451g |
NC_005967::47 827 |
G |
A |
1 |
16 |
c.271G>A |
p.Val91Ile |
|
PDR1 |
CAGL0A00451g |
NC_005967::47 849 |
T |
C |
1 |
16 |
c.293T>C |
p.Leu98Ser |
|
PDR1 |
CAGL0A00451g |
NC_005967::47 782 |
T |
C |
3 |
14 |
c.226T>C |
p.Ser76Pro |
|
PDR1 |
CAGL0A00451g |
NC_005967::47 983 |
A |
C |
3 |
14 |
c.427A>C |
p.Thr143Pro |
ID: gene ID; POS: SNP position; REF: reference allele; ALT: alternative allele; HGVS.c: Human Genome Variation Society – coding, represents the notation for describing DNA-level variations; HGVS.p: Human Genome Variation Society – protein, represents the notation for describing protein-level variations; No. of REF: counts of samples with reference allele at this locus; No. of ALT: counts of samples with alternative allele at this locus.