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. 2024 Jan 1;14(1):e2024038. doi: 10.5826/dpc.1401a38

Table 2.

Melanoma stage III subgroups according to the AJCC classification system 8th Edition.

N Category T Category
T0 Occult primary tumor T1a < 0.8 T1b < 0.8 U or 0.8–1.0 T2a >1.0–2.0 T2b >1.0–2.0 U T3a >2.0–4.0 T3b >2.0–4.0 U T4a >4.0 T4b >4.0 U
N1a 1 node c.o. N/A A A A B B C C C
N1b 1 node c.d B B B B B B C C C
N1c only S/T mets B B B B B B C C C
N2a 2/3 node c.o. N/A A A A B B C C C
N2b 2/3 node, at least 1 c.d. C B B B B B C C C
N2c S/T mets + 1 nodea C C C C C C C C C
N3a ≥4 node c.o. N/A C C C C C C C D
N3b ≥4 node, at least 1 c.d. or matted nodes C C C C C C C C D
N3c S/T mets + ≥2 nodea or matted nodes C C C C C C C C D

c.o. = clinically occult (diagnosed by sentinel node biopsy); c.d. = clinically detected (by palpation or imaging); N/A = not applicable. S/T mets = satellite and/or in-transit metastases. T category is expressed in mm.U = ulceration;

a

in N2c and N3c subcategories involved nodes may be either clinically occult or clinically detected.

Adapted from: Gershenwald JE, Scolyer RA, Hess KR, et al. Melanoma staging: evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017; doi:10.3322/caac.21409.