Figure 6. Glucose and lipid metabolism after pair feeding.
Body weight (A), glucose tolerance (B), and glucose tolerance AUC (C) at the end of the pair-feeding study (week 12) in male WT-ad-lib, MC4RF51L-ad-lib, and MC4RF51L pair-fed mice (n = 9–10/group). Body weight (D), glucose tolerance (E), and glucose tolerance AUC (F) at the end of the pair-feeding study in female mice (n = 8–15/group). Nonfasted serum glucose (G; n = 10–16/group for males and 9–16/group for females), insulin (H; n = 10–12/group for males and 9–16/group for females), leptin (I; n = 10–12/group for males and 9–16/group for females), triglycerides (J; n = 9–12/group for males and 8–16/group for females), and total cholesterol (K; n = 10–12/group for males and 9–16/group for females) at the end of the pair-feeding study. Data represent mean ± SEM. *P < 0.05, **P < 0.01 by 1-way ANOVA.