TABLE 4.
Splenocytes recover from unresponsiveness to ConA after fungal clearance
| Source of splenocytesa | Culture medium containing:
|
SIb | |
|---|---|---|---|
| NMMA | ConA | ||
| Normal mice | − | + | 10.7 |
| + | + | 10.5 | |
| Infected mice | − | + | 6.0 |
| + | + | 7.2 | |
a
Splenocytes were isolated from normal mice and mice inoculated 6 weeks previously with H. capsulatum. No fungus was recovered from the spleen at the time of the experiment. The size of the spleen had returned to a size comparable to that of a normal spleen.
b
The stimulation index (SI) is defined as the cpm of splenocytes from normal or infected mice stimulated with ConA divided by the cpm of splenocytes from normal or infected mice without ConA.