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. 2024 Feb 2;15:1345625. doi: 10.3389/fimmu.2024.1345625

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Copyright © 2024 Zheng, Liu, Zhou, Luo and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The figure illustrates the structure of P2X7R, which consists of transmembrane structural domains TM1 and TM2. The extracellular structural domain is represented by an orange line, which maintains the conformational stability through a disulfide bond. The carboxyl-terminal tail is very long and contains two homologous region sequences. Additionally, the figure shows the location of single nucleotide polymorphisms (SNPs) in the P2X7 receptor, with gain-of-function SNPs represented by blue dots and loss-of-function SNPs represented by green dots.