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. 2024 Feb 2;15:1345625. doi: 10.3389/fimmu.2024.1345625

Figure 2.

Figure 2

The figure illustrates the structure of P2X7R, which consists of transmembrane structural domains TM1 and TM2. The extracellular structural domain is represented by an orange line, which maintains the conformational stability through a disulfide bond. The carboxyl-terminal tail is very long and contains two homologous region sequences. Additionally, the figure shows the location of single nucleotide polymorphisms (SNPs) in the P2X7 receptor, with gain-of-function SNPs represented by blue dots and loss-of-function SNPs represented by green dots.