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. 2024 Feb 2;15:1275064. doi: 10.3389/fimmu.2024.1275064

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Copyright © 2024 Wu, Liu, Zhang, Ye, Gu, Jiang, Zhu, Ye, Li, Huang and Cao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of a TGF-β1 induced pulmonary fibroblast fibrosis model: DEGs identification and functional enrichment analysis. (A) Volcano plot displaying DEGs identified from RNA sequence data using the criteria adj.P.Val<0.0001, |log2FC|≥1.5, in which red points represent up-regulated genes, and blue points represent down-regulated. (B) Bubble chart presenting Gene Ontology (GO) and pathway enrichment analysis of RNAseq-DEGs. Bubble size indicates counts of respective GO category, and bubble color represents the adjusted p-value. (C) Functional network of enrichment analysis constructed by clusterProfiler, in which red points represent genes involved in similar functional GO terms or pathways. (D) Chord diagram illustrating functional relationships among RNAseq-DEGs and GO terms.