. 2024 Feb 2;37:11960. doi: 10.3389/ti.2024.11960

TABLE 4.

Results of Cox hazard regression analysis of variables associated with chronic active antibody-mediated rejection after active antibody-mediated rejection.

		Univariate				Multivariate
		HR¹	95% CI²		p-value	HR	95% CI		p-value
Recipient age	<56 years	reference
Recipient age	≥56 years	1.72	0.80	3.73	0.17
Donor age	<59 years	reference				reference
Donor age	≥59 years	2.68	1.20	6.01	0.02	2.51	1.12	5.64	0.03
Diabetes mellitus	Absence	reference
Diabetes mellitus	Presence	0.96	0.38	2.38	0.93
ABO compatibility	Compatible	reference
ABO compatibility	Incompatible	0.47	0.19	1.18	0.11
Number of transplantations	Primary	reference
Number of transplantations	Secondary	2.02	0.80	5.06	0.14
Number of HLA³ mismatches	<4	reference
Number of HLA³ mismatches	≥4	0.92	0.39	2.19	0.85
CDC⁴ for B cells	Negative	reference
CDC⁴ for B cells	Positive	1.22	0.28	5.25	0.79
FCXM⁵ for T cells	Negative	reference
FCXM⁵ for T cells	Positive	1.34	0.58	3.08	0.49
FCXM for B cells	Negative	reference
FCXM for B cells	Positive	2.17	0.63	7.47	0.22
Solid-phase immunoassay	Negative	reference
Solid-phase immunoassay	Positive	1.32	0.56	3.13	0.53
MFI⁶ of preformed DSA⁷	<5,000	reference
	≥5,000, <10,000	1.27	0.47	3.45	0.64
	≥10,000	1.89	0.69	5.17	0.21
MFI of de novo DSA	<3,000	reference
MFI of de novo DSA	≥3,000	0.67	0.20	2.25	0.52
eGFR⁸ before the treatments	<40 mL/min/1.73 m²	reference
eGFR⁸ before the treatments	≥40 mL/min/1.73 m²	0.69	0.32	1.47	0.33
i score at AABMR⁹ diagnosis	<2	reference
i score at AABMR⁹ diagnosis	≥2	1.73	0.23	12.9	0.59
t score at AABMR diagnosis	<2	reference
t score at AABMR diagnosis	≥2	3.31	0.77	14.3	0.49
g score at AABMR diagnosis	<2	reference
g score at AABMR diagnosis	≥2	1.96	0.91	4.26	0.09
ptc score at AABMR diagnosis	<2	reference
ptc score at AABMR diagnosis	≥2	1.43	0.66	3.09	0.36
C4d score at AABMR diagnosis	<2	reference
C4d score at AABMR diagnosis	≥2	0.97	0.43	2.16	0.94
MVI¹⁰ (g+ptc) at AABMR diagnosis	<4	reference				reference
MVI¹⁰ (g+ptc) at AABMR diagnosis	≥4	2.85	1.33	6.10	0.007	2.67	1.25	5.72	0.01
Coexistence of TCMR¹¹	Absence	reference
Coexistence of TCMR¹¹	Presence	0.75	0.10	5.60	0.78

HR¹, hazard ratio; CI², confidence interval; HLA³, human leucocyte antigen; CDC⁴, complement-dependent cytotoxity; FCXM⁵, flow cytometry crossmatch; MFI⁶, mean fluorescence intensity; DSA⁷, donor-specific antibody; eGFR⁸, estimated glomerular filtration rate; AABMR⁹, active antibody-mediated rejection; MVI¹⁰, microvascular inflammation; TCMR¹¹, T-cell mediated rejection.