Table 2.
MIC50 for vancomycin and gentamicin alone and in combination with TXA using the automatized turbidity method.
| Treatment | S. aureus MIC50 (ranges) mg/L | MIC50 fold reductions (no.) | S. epidermidis MIC50 (ranges) mg/L | MIC50 fold reductions (no.) | Overall MIC50 (ranges) mg/L | MIC50 fold reductions (no.) |
|---|---|---|---|---|---|---|
| Vancomycin | 4 (0.12–16) | 16 (16–16) | 8 (0.12–16) | |||
| Vancomycin+TXA 10 mg/ml | 0.03 (0.03–0.06) | 8 | 0.03 (0.03–0.03) | 8 | 0.03 (0.03–0.06) | 8 |
| Vancomycin+TXA 50 mg/ml | 0.12 (0.03–0.25) | 1 | 8 (0.03–16) | 1 | 4 (0.03–16) | 1 |
| Gentamicin | 16 (0.06–32) | 32 (32–32) | 32 (0.06–32) | |||
| Gentamicin+TXA 10 mg/ml | 0.06 (0.06–0.12) | 7 | 0.12 (0.06–0.25) | 8 | 0.12 (0.06–0.25) | 8 |
| Gentamicin+TXA 50 mg/ml | 8 (0.06–32) | 1 | 16 (0.06–32) | 1 | 16 (0.06–32) | 1 |
TXA, tranexamic acid; MIC, minimal inhibitory concentration.