Skip to main content
. 2024 Feb 15;9:32. doi: 10.1038/s41541-024-00823-1

Fig. 3. Prevention of brain pathology by ZPIV vaccination in hSTAT2KI mice.

Fig. 3

Representative images of the fetal brain from the mock-control (a, d), alum (b, e), or ZPIV (c, f) groups at 7 dpi. In the alum group, necrotic bodies (red circle) are scattered throughout the subventricular zone (SV), evident with loss of cellular density (b), which are absent in the fetal brain from the ZPIV group (c) comparable with those from the mock group (a). Coinciding with the brain pathology, ZIKV ENV proteins (blue arrow) were present in the subventricular zone in the alum group (e), but not in the ZPIV group (f), similar with the mock group (d). CP, choroid plexus, fRBC, fetal red blood cells, (arrowhead); SV, subventricular zone. Scale bars = 50 μm.