Table 5.

Summary of Definitions for OF and Grades of ACLF.

Failing organs	APASL AARC	EASL-CLIF	NACSELD
	Definition
Liver	Total bilirubin ≥5 mg/dL and INR ≥1.5	Bilirubin level of >12 mg/dL	-
Kidney	Acute kidney injury network criteria	Creatinine level of ≥2.0 mg/dL or renal replacement	Need for dialysis or other forms of renal replacement therapy
Brain	West-Haven HE grades 3–4	West-Haven HE grades 3–4	West-Haven HE grades 3–4
Coagulation	INR ≥1.5	INR ≥2.5	-
Circulation	–	Use of vasopressor (terlipressin and/or catecholamines)	Presence of shock defined by mean arterial pressure <60 mm Hg or a reduction of 40 mm Hg in systolic blood pressure from baseline, despite adequate fluid resuscitation and cardiac output
Respiration	–	PaO2/FiO2 of ≤200 or SpO2/FiO2 of ≤214 or need for mechanical ventilation	Need for mechanical ventilation
	AARC grades	EASL-CLIF ACLF grades	NACSELD ACLF grades
	AARC model: Bilirubin, INR, lactate, creatinine, HE grades. ACLF grades according to AARC model: Grade 1: 5-7 Grade 2: 8-10 Grade 3: 11-15	Grade 1: a.Single kidney failure b.Single liver, coagulation, circulatory, or lung failure that is associated with a serum creatinine level of 1.5–1.9 mg/dL and/or HE grade 1 or grade 2 c.Single brain failure with a serum creatinine level of 1.5–1.9 mg/dL Grade 2: 2 OF Grade 3: ≥3 OF	Grade 0: No OF Grade 1: Single OF Grade 2: Two OF Grade 3: Three OF Grade 4: Four or more OF

AARC-APASL AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; EASL-CLIF, European Association for the Study of Liver-Chronic Liver Failure; HE, hepatic encephalopathy; NACSELD, North American Consortium for the Study of End-Stage Liver Disease; OF, organ failure.