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. 2024 Feb 4;15(6):1750–1761. doi: 10.7150/jca.91089

Figure 1.

Figure 1

The expression of tumor B7-H3 was significantly associated with the tumor aggressiveness and survival outcome. A. B7-H3 proteins were mainly expressed on the membrane of cancer cells and partially expressed in the stromal cells. B. B7-H3 expression was higher than any other B7-CD28 family members. ***p<0.001. C. The H-score of tumor B7-H3 was statistically associated with tumor size (n=429, p=0.02). Early: pT1-2 and Late: pT3-4. D. Tumor B7-H3 expression was associated with risk of distant metastasis (n=429, p=0.011). E. Low tumor B7-H3 expression was significantly associated with favorable 5-year disease-free survival (DFS, n=429, Log-rank p=0.0004). F. Stratifying the level of tumor B7-H3 by mean expression (H-score), low tumor B7-H3 expression was significantly associated with favorable 5-year overall survival (OS, n=429, Log-rank p=0.02). G. Low CD276 mRNA was significantly associated with favorable survival outcome (OS, n=597, Log-rank p=0.008).