Table 1.

Univariate and multivariate analysis of DFS and known prognostic factors in colon carcinoma patients.

Parameters	Univariate analysis						Multivariate analysis
	No. at riska	Events	HR	95% CI	p value		HR	95% CI	p value
Sex	429	197
Female	204	95	1.0
Male	225	102	0.957	0.724-1.266	0.758
Age
<65	208	91	1
≥65	221	106	1.17	0.884-1.548	0.272
pT stage
pT1-2	71	17	1				1
pT3-4	358	180	2.566	1.560-4.221	<0.001		1.599	0.932-2.744	0.088
pN stage
Negative	223	71	1				1
Positive	206	126	2.475	1.848-3.315	<0.001		2.404	1.645-3.513	<0.001
Tumor location
Distal colon	181	83	1
Proximal colon	243	109	0.95	0.714-1.264	0.727
Tumor differentiation
Well to moderate	419	191	1
Poor	6	3	0.989	0.316-3.095	0.985
Lymphovascular invasion
Absent	184	58	1				1
Present	245	139	2.189	1.611-2.976	<0.001		1.386	0.970-1.982	0.073
Perineural invasion
Absent	260	90	1				1
Present	168	106	2.244	1.693-2.975	<0.001		1.616	1.179-2.215	0.003
Post-operative chemotherapy
No	175	64	1				1
Yes	254	133	1.524	1.131-2.054	0.006		0.578	0.392-0.852	0.006
Tumor EGFR
Negative	126	76	1
Positive	18	16	2.106	1.224-3.623	0.007
KRAS
WT	98	70	1
Mutation	56	41	1.065	0.724-1.566	0.750
Tumor B7H3
Low	215	80	1				1
High	214	117	1.657	1.246-2.203	0.001		1.492	1.114-1.997	0.007
Tumor PD-L1
High	144	51	1				1
Low	284	146	1.656	1.204-2.280	0.020		1.674	1.212-2.311	0.002
Tumor PD-L2
High	146	60	1
Low	274	132	1.296	0.955-1.759	0.096

^a: Number of cases may differ due to missing data.