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. 2024 Feb 1;15(6):1731–1732. doi: 10.7150/jca.93299

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circ_100395 suppresses the proliferation, migration, invasion and EMT in ovarian cancer cells, by sponging to miR-1228 and regulating p53 in ovarian cancer. (A) The expression level of p53 in circ_100395 or miR-1228 or p53 up-regulated ovarian cancer cells. (B) The overexpression of circ_100395 or miR-1228 or p53 regulate the proliferation of ES-2 cells in vitro using CCK-8 assay. (C) The overexpression of circ_100395 or miR-1228 or p53 significantly regulated the number of migrated and invaded cells in ES-2 cells, measured by Transwell assay. (D) Overexpression of circ_100395 or miR-1228 or p53 dramatically changed the expression of the epithelial marker, E-cadherin, while the mesenchymal markers, N-cadherin and Snail were contrarily regulated. *** P < 0.001.