Figure 5.

Anti‐tumor effect of SMDC‐Gd₄ in Gd‐NCT against CT26 tumor‐bearing mice. a) Schematic illustration of the therapeutic regimen for Gd‐NCT. Daily injections for three consecutive days were given, followed by thermal neutron irradiation (for 10 min, 5MW, fluence: 2.87 × 10¹² to 3.29 × 10¹² thermal neutrons cm⁻², 5.10 × 10¹¹ to 5.86 × 10¹¹ epithermal neutrons cm⁻²) directly toward subcutaneous solid tumors 24 h after the last injection. b) Relative tumor volumes in BALB/c mice. SMDC‐Gd₄ combined with radiation showed a significant anti‐tumor effect compared with other groups within 31 days after radiation. Data are shown as mean ± s.d., n = 5, n.s. p ≥ 0.05, ^⁎ p < 0.05. c) Bodyweight of mice. Data are shown as mean ± s.d., n = 5, n.s. p ≥ 0.05.