Table 1.
Relaxivities and relaxometric ratios of Gd‐conjugated contrast agents in water and bovine serum albumin (BSA) aqueous solutions at 0.47 T magnetic field.
| r 1 a) [s−1mm −1] | r 2 b) [s−1mm −1] | r 1/r 2 c) | r 1 with BSA d) [s−1mm −1] | r 2 with BSA e) [s−1mm −1] | r 1/r 2 with BSA f) | |
|---|---|---|---|---|---|---|
| Gd‐DOTA[ 35 ] | 3.4 | 4.1 | 0.83 | – | – | – |
| PEGA‐Gd4 | 19.6 ± 0.1 | 23.6 ± 0.1 | 0.83 | 21.4 ± 0.1 | 25.9 ± 0.1 | 0.83 |
| PEGA‐Gd12 | 20.4 ± 0.1 | 23.0 ± 0.1 | 0.89 | – | – | – |
| SMDC‐Gd4 (TP4) | 25.9 ± 0.1 | 31.1 ± 0.1 | 0.83 | 26.6 ± 0.1 | 32.1 ± 0.1 | 0.83 |
| SMDC‐Gd9 (TP5) | 22.8 ± 0.1 | 28.0 ± 0.1 | 0.81 | – | – | – |
| SMDC‐Gd17 (TP6) | 24.7 ± 0.1 | 29.6 ± 0.1 | 0.83 | 25.5 ± 0.1 | 30.8 ± 0.1 | 0.83 |
a)
Longitudinal relaxivity in water at 37 °C;
b)
Transverse relaxivity in water at 37 °C;
c)
Relaxometric ratio in water at 37 °C;
d)
Longitudinal relaxivity in 10 mg mL−1 BSA aqueous solution at 37 °C;
e)
Transverse relaxivity in 10 mg mL−1 BSA aqueous solution at 37 °C;
f)
Relaxometric ratio in 10 mg mL−1 BSA aqueous solution at 37 °C.