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. 2023 Dec 7;30(4):836–848. doi: 10.1158/1078-0432.CCR-23-2693

Figure 3.

Figure 3. LOF rearrangements. A, Relative prevalence of short variants (SV), copy-number deletions (CN), and rearrangements (RE) predicted to disrupt tumor suppressor genes: for all tumor suppressor genes (top), and for the top 15 rearranged tumor suppressor genes (bottom). CN is only reported for PTEN and BRCA1/2. B, Heatmap of the prevalence of the most frequently disrupted tumor suppressor genes in the pan-tumor cohort. Cancer types with ≥200 LBx and genes altered in >0.5% of at least 1 cancer type are shown.

LOF rearrangements. A, Relative prevalence of short variants (SV), copy-number deletions (CN), and rearrangements (RE) predicted to disrupt tumor suppressor genes: for all tumor suppressor genes (top), and for the top 15 rearranged tumor suppressor genes (bottom). CN is only reported for PTEN and BRCA1/2. B, Heatmap of the prevalence of the most frequently disrupted tumor suppressor genes in the pan-tumor cohort. Cancer types with ≥200 LBx and genes altered in >0.5% of at least 1 cancer type are shown.