Table 2.

Osteosarcoma PDX-derived cell line in vivo intravenous study summary table.

		OS152	OS742	OS525	OS052	OS526	OS186	OS384	OS457
# Mice Total [# Studies]		5 [2]	6 [1]	6 [2]	5 [2]	5 [2]	6 [2]	6 [3]	5 [1]
Endpoint (avg days)		53	55	80	85	140	160	168	168
Endpoint Decision with CS, if Applicable		BLI, CS	BLI, CS	CS	BLI	BLI	max	max	max
		abd mass	low BCS, gait	paralysis	N/A	N/A	N/A	N/A	N/A
Metastatic Sites (%)	Lung	100	100	67	100	100	N/A	100	N/A
	Bone	20	33	100	20	0	—	0	—
	Liver	60	100	67	0	0	—	0	—
	Other	20	33	33	20	0	—	0	—

Abbreviations: abd, abdominal; avg, average; BCS, body condition score; CS, clinical signs.