Table 4.
TWAS and colocalization with blood-based traits
| Cell type | Significant eGenes | Number of significant TWAS genes, shared | Number of significant TWAS genes, unique | Number of genes with coloc PP4 > 0.8, shared | Number of genes with coloc PP4 > 0.8, unique |
|---|---|---|---|---|---|
| Naïve B cells | 4,009 | 922 | 164 | 289 | 78 |
| Memory B cells | 3,571 | 1,582 | 207 | 511 | 106 |
| CD8 T cells | 2,875 | 1,276 | 168 | 414 | 93 |
| Naïve CD4 T cells | 3,082 | 1,349 | 183 | 445 | 88 |
| Resting memory CD4 T cells | 3,082 | 1,257 | 150 | 419 | 80 |
| Resting NK cells | 3,858 | 1,712 | 254 | 557 | 119 |
| Monocytes | 3,483 | 1,484 | 212 | 484 | 113 |
| Neutrophils | 4,629 | 969 | 159 | 331 | 60 |
| Bulk | 7,302 | 3,893 | / | 1,175 | / |
Shared refers to the number of significant (FDR <0.05) genes that are in common with the bulk TWAS-significant gene set, whereas unique refers to those that are not present in the bulk TWAS-significant gene set.