Table 1.
Summary of the observed mutation frequency and the estimated driver frequency for each gene among the top genes ranked by the estimated driver frequency in the RTK-RAS pathway from the InterMEL study
| Gene | Mutation frequency | Driver frequency |
|---|---|---|
| BRAF | 0.402 | 0.382 |
| NRAS | 0.196 | 0.196 |
| NF1 | 0.261 | 0.069 |
| KIT | 0.051 | 0.026 |
| FGFR4 | 0.091 | 0.010 |
| KRAS | 0.014 | 0.010 |
| MAPK1 | 0.032 | 0.009 |
| ALK | 0.131 | 0.009 |
| HRAS | 0.026 | 0.008 |
| JAK2 | 0.040 | 0.007 |
| ERBB2 | 0.065 | 0.006 |
| ERBB3 | 0.057 | 0.006 |
| NTRK2 | 0.065 | 0.005 |
| PTPN11 | 0.065 | 0.004 |
| RIT1 | 0.024 | 0.004 |
| MAP2K1 | 0.071 | 0.004 |
| MAP2K2 | 0.046 | 0.003 |
| IGF1R | 0.004 | 0.002 |