Figure 2.

Dose-response curve using tumor control probability model for the whole group (top) and for patients exposed to prior 0 to 2 lines of chemotherapy (bottom left) and ≥3 lines of chemotherapy (bottom right). The asymmetrical error bars on local control rate (y-axis) indicate 95% confidence interval based on the Clopper-Pearson method. The x-error bars were estimated from the conversion of the standard error of the total local control rate into the uncertainty of the equivalent dose. Abbreviations: γ50 = the slope of the curve at TD50; EQD2 = 2 Gy dose equivalent; TD₅₀ = tumor dose at which 50% of tumor control probability is expected.