Table 4.
Cancellous bone histomorphometry of 1 month old Notch3em2.1Ecan (Hprt-Cre;Notch3INV/WT) male mice and sex-matched wild type littermates (controls).
| Males | ||
|---|---|---|
| Cancellous Bone | Control n = 5 | Notch3INV n = 4 |
| Static Histomorphometry | ||
| Bone Volume/Tissue Volume (%) | 16.3 ± 2.8 | 9.6 ± 5.0* |
| Trabecular Separation (μm) | 195 ± 26 | 355 ± 152* |
| Trabecular Number (1/mm) | 4.3 ± 0.4 | 2.8 ± 0.9* |
| Trabecular Thickness (μm) | 38 ± 5 | 32 ± 1 |
| Osteoblast Surface/Bone Surface (%) | 21.2 ± 4.8 | 21.6 ± 8.6 |
| Osteoblasts/Bone Perimeter (1/mm) | 16.8 ± 4.6 | 17.4 ± 6.3 |
| Osteoid Surface/Bone Surface (%) | 1.7 ± 0.9 | 1.2 ± 0.9 |
| Osteoclast Surface/Bone Surface (%) | 9.7 ± 2.5 | 9.8 ± 4.7 |
| Osteoclasts/Bone Perimeter (1/mm) | 3.6 ± 0.9 | 3.6 ± 1.8 |
| Eroded Surface/Bone Surface (%) | 2.3 ± 0.8 | 2.0 ± 1.5 |
Histomorphometry was carried out on sagittal sections of distal femurs. Values are means ± S.D.
*
Significantly different between control and Notch3em2.1Ecan mice, p < 0.05 by unpaired t-test.