Table 3.

START:REACTS study planning and observed trial data. Numbers of participants providing outcome data at 3, 6 and 12 months, information ($\text{I}=1/\text{var}({\beta }_s)$) and test statistic ($Z={\beta }_s/\text{sd}({\beta }_s)$) boundaries in [a] the expected (planned) study design based on extensive simulations and [b] observed in the trial itself. Note that the trial was stopped at the first interim analysis for futility, as the test statistic fell below the lower boundary

[a] Expected					[b] Observed
Outcome		Interim		End	Interim		End
		1	2		1	2
12 months	$N_3$	50	70	188	47	-	-
6 months	$N_2$	90	110	188	86	-	-
3 months	$N_1$	120	140	188	112	-	-
Information	I	0.102	0.139	0.326	0.110	-	-
Information fraction	$\tau$	0.311	0.426	1.000	-	-	-
Test statistic	Z	-	-	-	-0.881	-	-
Boundary	lower	-0.706	0.581	1.909	-	-	-
	upper	$\infty$	3.090	1.909	-	-	-