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. 2024 Jan 17;124(3):889–928. doi: 10.1021/acs.chemrev.3c00579

Figure 22.

Figure 22

Unnatural lipids for membrane targeting. (a) Generation of a modified N-Ras protein bearing a lipid mimic via uAA incorporation results in membrane localization.158 (b) Insertion of a cycloalkyne into a lipid and subsequent coupling to a coumarin fluorophore probe allows lipid tracking.132