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. 2024 Jan 17;124(3):889–928. doi: 10.1021/acs.chemrev.3c00579

Figure 26.

Figure 26

Exploiting pseudo-organelles.166,167 (a) Organelle-membrane-specific peptide tags were used to target mRNA binding proteins, phase separation proteins (to promote film formation), and orthogonal aaRSs to specific subcellular locations. (b) Multiple proteins bearing uAAs could be synthesized selectively at given locations within the cell. ECM = extracellular matrix.