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. 2024 Jan 17;124(3):889–928. doi: 10.1021/acs.chemrev.3c00579

Figure 29.

Figure 29

An approach for the expansion of small-molecule-mediated covalent inhibition. MEK1 kinase can be targeted over MEK2 kinase using a modified inhibitor that targets uAAs, thereby conferring selectivity when in a live mammalian cell culture179