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Tissuoselectivity via a “pro-metabolite” for metabolic labeling. (a) Incorporation of azides into tumor tissue as a strategy for selective tumor tissue targeting. (b) An O-1-protected ManAz “pro-metabolite”—named DCL-AAM—is suggested as being selectively deprotected through the sequential action of two enzymes that are overexpressed in tumors, allowing for selective incorporation into cell-surface glycans in that tissue.68 Abbreviations are as follows: CTSL = cathepsin L.
