Table 2.

The odds ratio (95% confidence interval) of breast cancer based on the different high protein scores in tertiles or per increment of one standard deviation among the study population

	OR of breast cancer (95% CI)
	T1	T2	T3	P trend	Per one SD	P-value
High-protein-low-CHO and fat diet
Median score, SD	12.0	17.0	21.0	-	3.83	-
Case/total	58 / 138	36 / 133	40 / 130	-	134 / 401	-
Model 1a	1.00 (Ref)	0.52 (0.31–0.89)	0.65 (0.39–1.08)	0.068	0.80 (0.65–1.00)	0.045
Model 2b	1.00 (Ref)	0.45 (0.26–0.78)	0.58 (0.34–1.00)	0.031	0.77 (0.61–0.96)	0.022
Model 3c	1.00 (Ref)	0.39 (0.22–0.69)	0.48 (0.27–0.85)	0.008	0.71 (0.56–0.90)	0.005
High-protein and CHO-low-fat score
Median score, SD	10.0	18.0	24.0	-	6.73	-
Case/total	58 / 156	42 / 118	34 / 127	-	134 / 401	-
Model 1a	1.00 (Ref)	0.96 (0.57–1.60)	0.66 (0.39–1.11)	0.143	0.85 (0.69–1.06)	0.146
Model 2b	1.00 (Ref)	0.91 (0.53–1.55)	0.63 (0.36–1.10)	0.115	0.81 (0.64–1.02)	0.070
Model 3c	1.00 (Ref)	0.84 (0.49–1.45)	0.58 (0.33–1.01)	0.061	0.76 (0.60–0.97)	0.026
High-protein and fat-low-CHO score
Median score, SD	10.0	17.0	23.0	-	5.92	-
Case/total	49 / 139	43 / 135	42 / 127	-	134 / 401	-
Model 1a	1.00 (Ref)	0.82 (0.49–1.37)	0.89 (0.53–1.50)	0.631	0.99 (0.80–1.22)	0.913
Model 2b	1.00 (Ref)	0.72 (0.42–1.24)	0.91 (0.52–1.58)	0.655	0.99 (0.79–1.24)	0.941
Model 3c	1.00 (Ref)	0.73 (0.42–1.25)	0.91 (0.52–1.59)	0.665	0.99 (0.79–1.24)	0.908

CHO Carbohydrate

^aModel 1: adjusted for age, first pregnancy age

^bModel 2: adjusted for model 1 and menopausal status, family history of cancer, anti-inflammatory drug use, Vitamin D supplementation, physical activity, body mass index, and socio-economic status

^cModel 3: adjusted for model 2 and energy intake