Table 1:
Demographics and characteristics of cases and controls in the Lynch syndrome colorectal cancer study
| Lynch | Sporadic | |||
|---|---|---|---|---|
|
|
||||
| Colorectal cancers | Benign colorectum mucosa | Colorectal cancers | Benign colorectum mucosa | |
|
|
||||
| N | 23 | 32 | 48 | 48 |
| Germline LS gene mutation, N (%)* | 23 (100%) | 32 (100%) | - | - |
| MLH1 | 6 (25%) | 7 (21%) | - | - |
| MSH2 | 9 (38%) | 15 (44%) | - | - |
| MSH6 | 6 (25%) | 8 (24%) | - | - |
| PMS2 | 2 (8%) | 4 (12%) | - | - |
| EPCAM | 1 (4%) | 0 (0%) | - | - |
| Age, median [IQR] | 48 [42–57] | 47 [42–60] | 49 [44–59] | 48 [38–56] |
| Caucasian (%) | 21 (91%) | 28 (88%) | 40 (83%) | 47 (98%) |
| Females (%) | 8 (35%) | 20 (62%) | 15 (31%) | 22 (46%) |
| Tobacco use, current (%) | 6 (26%) | 3 (9%) | 7 (15%) | 6 (12%) |
| Site, proximal (%) | 13 (57%) | - | 17 (35%) | - |
| Stage (%) | ||||
| I | 10 (43%) | 7 (15%) | ||
| II | 6 (26%) | 8 (17%) | ||
| III | 7 (30%) | 21 (44%) | ||
| IV | 0 (0%) | 12 (25%) | ||
IQR, interquartile range; LS, Lynch Syndrome
*
Some patients had more than one mutation: One cancer and one benign had MSH2 and MSH6 and one benign had MLH1 and PMS2