Table 10.
Secondary Outcomes: Grade 3 Bronchopulmonary Dysplasia (Invasive Mechanical Ventilation; Jensen and Colleagues) Outcome at 36 Weeks Postmenstrual Age (Limited to Importance 0.0005 or More)
| Variable (Selected by LASSO) | AUC C-Statistic | Importance of Variable | OR (95% CI) | P Value |
|---|---|---|---|---|
| Clinical variables alone model | 0.887 | |||
| IMV | 0.0207 | 6.96 (3.11–15.56) | <0.00001 | |
| Sedatives | 0.0125 | 4.44 (1.97–10) | 0.0003 | |
| SGA | 0.0067 | 3.75 (1.70–8.25) | 0.001 | |
| Apgar 1-min score | 0.0063 | 0.72 (0.53–1.0) | 0.0465 | |
| Gestational age | 0.0027 | 0.68 (0.47–1.0) | 0.050 | |
| Black race | 0.0020 | 1.79 (1.03–3.13) | 0.0396 | |
| FiO2 high | 0.0006 | 2.25 (1.15–4.43) | 0.0185 | |
| Physiologic variables alone model | 0.871 | |||
| IH80 dpe | 0.0614 | 1.70 (1.18–2.45) | 0.0047 | |
| PB daily duration | 0.0056 | 0.02 (0.01–0.50) | 0.0183 | |
| Apnea daily duration | 0.0025 | 0.60 (0.31–1.18) | 0.138 | |
| Combined model (physiologic model + clinical model) | 0.900 | |||
| Sedatives | 0.0164 | 4.78 (1.65–13.86) | 0.004 | |
| SGA | 0.0092 | 4.01 (1.66–9.71) | 0.002 | |
| IH80 dpe | 0.0087 | 1.60 (1.02–2.53) | 0.042 | |
| Gestational age | 0.0087 | 0.57 (0.38–0.87) | 0.009 | |
| PB daily duration | 0.0042 | 0.05 (0.01–0.72) | 0.027 | |
| Apnea daily duration | 0.0025 | 0.50 (0.23–1.08) | 0.079 | |
| Apgar 1-min score | 0.0009 | 0.83 (0.51–1.34) | 0.442 | |
| Steroids | 0.0008 | 0.51 (0.22–1.18) | 0.118 | |
| Apgar 5-min score | 0.0008 | 0.82 (0.54–1.25) | 0.361 | |
| Hispanic ethnicity | 0.0006 | 0.70 (0.32–1.53) | 0.369 | |
| IMV | 0.0005 | 2.80 (1.04–7.51) | 0.041 |
Definition of abbreviations: AUC = area under the curve; CI = confidence interval; dpe = duration per event; IH80 = intermittent hypoxemia events with oxygen saturation as measured by pulse oximetry <80%; IMV = invasive mechanical ventilation; LASSO = least absolute shrinkage and selection operator; OR = odds ratio; PB = periodic breathing; SGA = small for gestational age.