Table 8.

Secondary Outcomes: Highly Unfavorable Outcome at 40 Weeks Postmenstrual Age (Limited to Importance 0.0005 or More)

Variable (selected by LASSO)	AUC C-Statistic	Importance of Variable	OR (95% CI)	P Value
Clinical variables alone model	0.862
IMV		0.0156	3.92 (1.65–9.32)	0.002
Gestational age		0.0135	0.52 (0.33–0.80)	0.003
SGA		0.0133	4.77 (2.11–10.76)	0.0002
FiO2*		0.0024	1.28 (0.95–1.72)	0.101
Male		0.0018	1.80 (0.96–3.39)	0.068
Apgar 1-min score		0.0016	0.79 (0.55–1.12)	0.183
Hispanic ethnicity		0.0005	0.49 (0.20–1.20)	0.120
Physiologic variables alone model	0.842
IH80 dpe		0.0490	1.86 (1.27–2.71)	0.001
PB count		0.0047	0.13 (0.01–2.37)	0.170
Bradycardia daily duration		0.0013	1.32 (1.02–1.71)	0.038
Combined model (physiologic model + clinical model)	0.872
SGA		0.0134	4.73 (1.98–11.31)	0.0005
Gestational age		0.0112	0.50 (0.33–0.76)	0.001
Sedatives		0.0065	3.10 (1.26–7.65)	0.014
IH80 dpe		0.0056	1.69 (1.03–2.78)	0.038
Hispanic ethnicity		0.0025	0.45 (0.19–1.09)	0.078
IH90 count		0.0013	1.24 (0.90–1.71)	0.192
IH90 dpe		0.0013	1.50 (0.93–2.41)	0.097

Definition of abbreviations: AUC = area under the curve; CI = confidence interval; dpe = duration per event; IH80 = intermittent hypoxemia events with oxygen saturation as measured by pulse oximetry <80%; IH90 = intermittent hypoxemia events with oxygen saturation as measured by pulse oximetry <90%; IMV = invasive mechanical ventilation; LASSO = least absolute shrinkage and selection operator; OR = odds ratio; PB = periodic breathing; SGA = small for gestational age.

^*When Fi_O2 is listed as a variable, it is the continuous variable of Fi_O2 value closest to noon. If Fi_O2 >0.3 is listed, it is the binary variable Fi_O2 >0.3.