Table 9.

Secondary Outcomes: Moderate-Severe Bronchopulmonary Dysplasia (Eunice Kennedy Shriver National Institute of Child Health and Human Development) Outcome at 36 Weeks Postmenstrual Age (Limited to Importance 0.0005 or More)

Variable (Selected by LASSO)	AUC C-Statistic	Importance of Variable	OR (95% CI)	P Value
Clinical variables alone model	0.883
IMV		0.0182	9.47 (4.87–18.43)	<0.00001
FiO2*		0.0104	1.87 (1.23–2.84)	0.0035
Positive pressure		0.0094	4.10 (2.37–7.08)	<0.00001
Supplemental oxygen >12 h/24 h		0.0072	3.94 (2.26–6.86)	<0.00001
SGA		0.0051	4.22 (2.06–8.67)	<0.0001
Apgar 5-min score		0.0014	0.77 (0.62–0.96)	0.0213
Caffeine		0.0007	0.66 (0.26–1.71)	0.397
Physiologic variables alone model	0.875
IH90 dpe		0.0122	2.78 (1.83–4.20)	<0.00001
IH90 daily duration		0.0084	1.95 (1.46–2.61)	0.00001
Apnea dpe		0.0014	0.82 (0.64–1.06)	0.128
Combined model (physiologic model + clinical model)	0.894
FiO2*		0.0102	1.84 (1.22–2.79)	0.0038
Positive pressure		0.0059	3.53 (1.82–6.84)	0.0002
Black race		0.0059	0.50 (0.29–0.86)	0.012
IH90 daily duration		0.0057	1.62 (1.20–2.19)	0.002
SGA		0.0035	4.12 (1.80–9.43)	0.001
Apnea dpe		0.0032	0.73 (0.54–1.0)	0.047
IMV		0.0026	3.85 (1.62–9.15)	0.002
Supplemental oxygen		0.0023	2.78 (1.19–6.51)	0.019
Hispanic ethnicity		0.0021	0.58 (0.27–1.25)	0.165
Apgar 5 min		0.0020	0.71 (0.55–0.92)	0.009

Definition of abbreviations: AUC = area under the curve; CI = confidence interval; dpe = duration per event; IH90 = intermittent hypoxemia events with oxygen saturation as measured by pulse oximetry <90%; IMV = invasive mechanical ventilation; LASSO = least absolute shrinkage and selection operator; OR = odds ratio; PB = periodic breathing; SGA = small for gestational age.

^*When Fi_O2 is listed as a variable, it is the continuous variable of Fi_O2 value closest to noon. If Fi_O2 >0.3 is listed, it is the binary variable Fi_O2 >0.3.