Table 1.

Data from Hospital-based Cohort Studies Conducted in Six African Countries from 2009 through 2019

Study	Year	Site	Inclusion Criteria	Total (n)	In-Hospital Mortality (%)	Average Missing Clinical Data per Patient (%)^*	Missing Oxygen Saturation per Study (%)	Missing HIV Data per Study (%)
Adakun	2013	Uganda	Meningitis^†	141	28	12	100	0
Amir	2016	Uganda	Sepsis^‡	206	31	15	100	1
Andrews	2013	Zambia	Sepsis^‡	209	41	15	10	2
Andrews	2014	Zambia	Sepsis^‡	109	62	14	30	0
Auma	2013	Uganda	Sepsis^§	216	19	13	100	22
Huson	2015	Gabon	Sepsis^ǁ	381	4	13	3	0
Jacob	2009	Uganda	Sepsis^‡	381	24	13	100	16
Jacob	2012	Uganda	Sepsis^‡	423	25	4	5	0
Majwala	2013	Uganda	Meningitis^†	145	32	13	100	0
Opio	2013	Uganda	Hospitalized^¶	1,664	7	17	23	66
Roth	2015	Sierra Leone	Fever^**	429	19	21	100	94
Rubach	2015	Tanzania	Fever^††	400	11	1	1	3
Rylance	2009	Tanzania	Hospitalized^¶	694	11	6	16	100
Ssekitoleko	2011	Uganda	Sepsis^§	150	30	13	100	13
Wheeler	2013	Malawi	Hospitalized^¶	355	23	2	0	19
Unpublished	2019	Uganda^‡‡	Hospitalized^¶	1,482	7	4	1	4
Total	—	—	—	7,385	15	10	39	33

The data from these hospital-based cohort studies contributed to pooled data for the analysis of the prevalence, characteristics, and outcomes of World Health Organization–defined severe respiratory disease without shock.

Clinical data include temperature, heart rate, respiratory rate, systolic blood pressure, diastolic blood pressure, and Glasgow Coma Scale score.

^{^†}

Admitted with a clinical diagnosis of meningitis.

^{^‡}

Admitted with a clinical diagnosis of severe sepsis, defined as systemic inflammatory response syndrome with suspected infection and organ dysfunction.

^{^§}

Admitted with a clinical diagnosis of sepsis defined as systemic inflammatory response syndrome with suspected infection.

^{^ǁ}

Admitted with a temperature ⩾38°C or <36°C and at least one other systemic inflammatory response syndrome criterion.

^{^¶}

Admitted with an acute illness to a medical ward with no other specified inclusion criteria.

^**

Admitted with subjective fever or had a documented temperature ⩾38°C within 24 hours of admission.

^{^††}

Admitted with a temperature ⩾38.0°C.

^{^‡‡}

Kitovu Hospital, Masaka, Uganda.