. 2023 Aug 23;209(1):59–69. doi: 10.1164/rccm.202303-0444OC

Table 3.

Effect of Different Prediction Equations on Disease Severity Classification in COPDGene Participants

	Race	GOLD Stage 0	PRISm	GOLD Stage 1	GOLD Stage 2	GOLD Stage 3	GOLD Stage 4
Multiethnic prediction equations
1.NHANES race-specific (reference)	NHW	2,515	695	674	1,468	922	492
2.NHANES AA applied to NHW	NHW	3,023	187	1,289	1,194	743	330
3.GLI race-specific (NHW)	NHW	2,571	639	698	1,454	912	492
4.GLI AA applied to NHW	NHW	3,023	187	1,267	1,221	743	325
5.GLI Other applied	NHW	2,843	367	955	1,359	824	418
6.GLI Global applied	NHW	2,774	436	859	1,405	855	437
1.NHANES race-specific (reference)	AA	1,791	525	194	495	245	116
2.NHANES NHW applied to AA	AA	1,017	1,299	63	485	331	171
3.GLI race-specific (AA)	AA	1,747	569	185	492	258	115
4.GLI NHW applied to AA	AA	1,046	1,270	64	490	328	168
5.GLI Other applied	AA	1,416	900	105	519	286	140
6.GLI Global applied	AA	1,319	997	93	515	291	151
Race-free (neutral) prediction equations
% Predicted by (FEV₁/height²) × 100	NHW	2,515	695	757	1,311	960	528
% Predicted by (FEV₁/height²) × 100	AA	1,518	798	145	436	301	168

Definition of abbreviations: AA = African American; COPDGene = Genetic Epidemiology of Chronic Obstructive Pulmonary Disease; GLI = Global Lung Function Initiative; GOLD = Global Initiative for Chronic Obstructive Lung Disease; NHANES = National Health and Nutrition Examination Survey; NHW = non-Hispanic white; PRISm = preserved ratio impaired spirometry.