Fig. 4.

MNPs-TRPV1 suppresses macrophagic inflammation under AMF exposure in vivo. (A) Timeline for the intra-articular injection of MNPs-TRPV1 and subsequent AMF stimulation. (B and C) Mouse weight (B) and knee diameter (C) of mice at the endpoint of animal experiments. (D and E) Representative images (D) of H&E staining of mouse knee sections and the quantified synovitis scores (E). (F to J) Representative images (f) of immunofluorescence or immunohistochemical staining and quantification of Cd14⁺ (G) and Cd86⁺ (H) cells, as well as the relative Tnf-α (I) and Il-6 (J) density in the synovium. w/o, without; w/, with. Scale bars, 50 μm. One-way ANOVA with Tukey’s post hoc test. Data are shown as mean ± SD.