Table 2.
The pocket volume (Å3) and solvent accessible surface area (SASA) (Å2) of the active site pocket.
| System | WT | V211A | V211G | G214A | G214R | E219A | E219G | E219K | Y221A | Y221H |
|---|---|---|---|---|---|---|---|---|---|---|
| Volume (Å3) | 1071.81±157.54 | 1182.23±200.19 | 1181.68±187.35 | 1075.46±259.79 | 1115.24±241.80 | 1206.33±221.87 | 1211.74±250.02 | 1278.62±293.00 | 1381.32±302.32 | 1210.70±182.42 |
| SASA (Å2) | 391.07±11.59 | 391.73±10.13 | 391.54±10.75 | 394.02±13.32 | 398.51±17.83 | 396.92±12.13 | 400.31±14.64 | 40.67±1.71 | 406.73±17.07 | 399.28±10.32 |