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[Preprint]. 2025 Mar 3:2024.02.01.578450. Originally published 2024 Feb 5. [Version 2] doi: 10.1101/2024.02.01.578450

Figure 3|. DNA methylation in brains affected by Alzheimer’s disease.

Figure 3|

A) Meta-chromosome of the rolling mean of the difference in methylation values of differentially methylated regions across all autosomes and normalized for chromosome length for Braak III vs. Braak 0 and Braak V/VI vs. Braak 0. Horizontal dashed lines represent the average change across the whole meta-chromosome for each Braak stage. B) Permutation test of differentially methylated regions localized to the centromere in Braak III vs. Braak 0 and Braak V/VI vs. Braak 0, P=0.0001. C, D) Karyotype of example chromosomes with significant changes in methylation in Braak III and Braak V/VI. E) Permutation test of differentially methylated regions localized to rDNA arrays in Braak III vs. Braak 0 and Braak V/VI vs. Braak 0, P=0.0001. F) Box/violin plot of areaStat values for differentially methylated regions between Braak III vs. Braak 0 and Braak V/VI vs. Braak 0.