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[Preprint]. 2024 Feb 11:2024.02.09.579083. [Version 1] doi: 10.1101/2024.02.09.579083

navigate: an open-source platform for smart light-sheet microscopy

Zach Marin, Xiaoding Wang, Dax W Collison, Conor McFadden, Jinlong Lin, Hazel Borges, Bingying Chen, Dushyant Mehra, Qionghua Shen, Seweryn Galecki, Stephan Daetwyler, Reto Fiolka, Kevin M Dean
PMCID: PMC10871345  PMID: 38370811

Abstract

navigate is a turnkey, open-source software solution designed to enhance light-sheet fluorescence microscopy (LSFM) by integrating smart microscopy techniques into a user-friendly framework. It enables automated, intelligent imaging with a Python-based control system that supports GUI-reconfigurable acquisition routines and the integration of diverse hardware sets. As a comprehensive package, navigate democratizes access to advanced LSFM capabilities, facilitating the development and implementation of smart microscopy workflows without requiring deep programming knowledge or specialized expertise in light-sheet microscopy.

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