Skip to main content
. 2005 May 2;115(5):1306–1313. doi: 10.1172/JCI23109

Figure 4.

Figure 4

Effect of acute downregulation of IR protein on hepatic glucose fluxes during insulin clamp studies. (A) Glucose flux through G6Pase in mice treated with high-dose IR antisense compared with that of controls. (B) Effect of treatment with high-dose IR antisense compared with that of control on glycogenolysis expressed as % of G6Pase flux. (C) Effect of treatment with high-dose IR antisense compared with that of control on GNG as % of G6Pase flux. (D) Effect of treatment with high-dose IR antisense compared with that of control on hepatic G6Pase and PEPCK mRNA levels assessed in the liver of mice completing the clamp procedure. (E) Effect of treatment with high-dose IR antisense compared with that of control on hepatic G6Pase and PEPCK mRNA levels assessed in the liver of fasted mice. *P < 0.05 vs. control-ASO–treated group; #P < 0.01 vs. control-ASO–treated group.