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Primary end point. (A) Change from baseline in ELF score at week 48. (B–D) Change from baseline to week 48 in the individual components of ELF: HA (B), PIIINP (C), and TIMP-1 (D). Shown are LS mean differences between the aldafermin group (1 or 3 mg) and the placebo group. Enrollment in the aldafermin 0.3 mg group was discontinued during the trial. Abbreviations: ELF, Enhanced Liver Fibrosis; HA, hyaluronic acid; LS, least-squares; PIIINP, N-terminal pro-peptide of type III collagen.
