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. 2023 Apr 4;82(3):168–178. doi: 10.1159/000529637

Table 3.

Polygenic risk score results for remission status and relapse in the European ancestry subsample

Polygenic risk scores Remission status (N = 143) Relapse status (N = 73)
OR [95% CI] p value Per-P OR [95% CI] p value Per-P
ALZ (IGAP 1) [38] 1.34 [0.90, 1.99] 0.15 0.45 0.006 [0.0002, 0.14] 0.002 0.01*
ALZ (IGAP 1–2 meta-analysis) [38] 0.91 [0.63, 1.32] 0.63 0.91 0.38 [0.18, 0.80] 0.01 0.03*
ALZ [39] 1.53 [0.91, 2.57] 0.11 0.39 0.73 [0.40, 1.36] 0.32 0.81
BPD [37] 2.39 [0.16, 36.14] 0.53 0.96 a
MDD (PGC) [34] 1.10 [0.68, 1.79] 0.70 0.99 0.64 [0.34, 1.20] 0.16 0.40
MDD (PGC) [33] 0.85 [0.56, 1.28] 0.43 0.66 0.72 [0.38, 1.37] 0.32 0.51
AD non-remission (PGC) [35] 0.70 [0.41, 1.20] 0.19 0.61 1.81 [0.93, 3.51] 0.08 0.33
AD improvement (PGC) [35] 1.95 [1.20, 3.17] 0.007 0.04* 1.92 [1.05, 3.53] 0.03 0.17
SCZ [36] 1.56 [1.04, 2.33] 0.03 0.09 0.82 [0.36, 1.84] 0.62 0.96
All stroke [40] 1.46 [0.97, 2.21] 0.07 0.26 0.19 [0.04, 0.88] 0.03 0.15
Ischemic stroke 0.81 [0.41, 1.58] 0.54 0.96 0.27 [0.06, 1.28] 0.10 0.37
Cardioembolic stroke 1.80 [0.88, 3.71] 0.11 0.39 0.15 [0.01, 1.58] 0.11 0.35
Large vessel stroke 2.15 [0.35, 13.22] 0.41 0.90 1.86 [0.64, 5.41] 0.25 0.70
Small vessel stroke 1.33 [0.73, 2.41] 0.36 0.85 a

AD, antidepressant; ALZ, Alzheimer’s disease; BPD, bipolar disorder; CI, confidence interval; IGAP, the International Genomics of Alzheimer’s Project; MDD, major depressive disorder; OR, odds ratio; p, p value; Per-P, permutation p value; PGC, Psychiatric Genomics Consortium; SCZ, schizophrenia.

*p < 0.05 (number of permutation testing = 10,000).

aModel did not converge.

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