Table 2.

One-Pot Optimization Toward Fluorescent Pyrido-imidazo[4,5-c]isoquinolines

Entrya	Acid (eq.)	Solvent (0.3 M)	Time (min)	Yield (%)
1	Cu(OTf)2(1.0)	MeOH	5	0
2	Cu(OTf)2(1.0)	DCMb	20	0
3	Cu(OTf)2(1.0)	ACN	20	0
4	-	AcOH	20	28
5	H2SO4(30 eq.)	AcOH	20	6
6	H2SO4(50 eq.)	MeOH	20	0
7	H2SO4(50 eq.)	MeOH	20, 5c	81
8	H2SO4(50 eq.)	MeOH	20, 10c	87
9	H2SO4(50 eq.)	MeOH	20, 20c	96

^aScale: 1.0 mmol

^b100 °C

^cAcid was added after 1^st indicated time and set to run for the 2^nd indicated time at 140 °C (microwave irradiation).